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Moreth, K. ; Fischer, R. ; Fuchs, H. ; Gailus-Durner, V. ; Wurst, W. ; Katus, H.A.* ; Bekeredjian, R.* ; Hrabě de Angelis, M.

High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.

J. Comp. Physiol. B 184, 763-775 (2014)

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Open Access Green as soon as Postprint is submitted to ZB.

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Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function.

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