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Tan, S.* ; Scherag, A.* ; Janssen, O.E.* ; Hahn, S.* ; Lahner, H.* ; Dietz, T.* ; Scherag, S.* ; Grallert, H. ; Vogel, C.I.G.* ; Kimmig, R.* ; Illig, T. ; Mann, K.* ; Hebebrand, J.* ; Hinney, A.*

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

BMC Med. Genet. 11:12 (2010)

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BACKGROUND: The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etiology and the role of IR and obesity in PCOS are not fully understood. We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS. METHODS: We conducted an association study in 386 patients with PCOS (defined by the Rotterdam-criteria) using single nucleotide polymorphisms (SNPs) in or in proximity to the fat mass and obesity associated gene (FTO), insulin-induced gene-2 (INSIG2), transcription factor 7-like 2 gene (TCF7L2) and melanocortin 4 receptor gene (MC4R). To compare the effect of FTO obesity risk alleles on BMI in patients with PCOS to unselected females of the same age range we genotyped 1,971 females from the population-based KORA-S4 study (Kooperative Gesundheitsforschung im Raum Augsburg, Survey 4). RESULTS: The FTO risk allele was associated with IR traits and measures of increased body weight. In addition, the TCF7L2 SNP was associated with body weight traits. For the SNPs in the vicinity of INSIG2 and MC4R and for the other examined phenotypes there was no evidence for an association. In PCOS the observed per risk allele effect of FTO intron 1 SNP rs9939609 on BMI was +1.56 kg/m2, whereas it was +0.46 kg/m2 in females of the same age range from the general population as shown previously. CONCLUSION: The stronger effect on body weight of the FTO SNP in PCOS might well have implications for the etiology of the disease.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Genome-wide association; Beta-cell function; TCF7L2 gene; Common variants; Nondiabetic individuals; Metabolic syndrome; Receptor gene; Population; Risk; Polymopphisms

e-ISSN 1471-2350

Journal BMC Medical Genetics

Quellenangaben Volume: 11, Issue: 1, Article Number: 12

Publisher BioMed Central

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)