PuSH - Publication Server of Helmholtz Zentrum München: An approximative approach for single cell spatial modeling of quorum sensing.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Gölgeli Matur, M. ; Müller, J. ; Kuttler, C. ; Hense, B.A.

An approximative approach for single cell spatial modeling of quorum sensing.

J. Comput. Biol. 22, 227-235 (2015)

Publ. Version/Full Text

DOI

PMC

	Licenced for HMGU

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Abstract Quorum sensing, a special kind of cell-cell communication, has originally been described for well-mixed homogeneous bacterial cultures. However, recent perception supports its ecological relevance for spatially heterogeneous distributed cells, like colonies and biofilms. New experimental techniques allow for single cell analysis under these conditions, which is crucial to understanding the effect of chemical gradients and intercell variations. Based on a reaction-diffusion system, we develop a method that drastically reduces the computational complexity of the model. In comparison to similar former approaches, handling and scaling is much easier. Via a suitable scaling, this approach leads to approximative algebraic equations for the stationary case. This approach can be easily used for numerical situations.

Altmetric

Additional Metrics?

[➜Log in]