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Deshpande, A.J. ; Cusan, M. ; Rawat, V.P.S. ; Reuter, H. ; Krause, A. ; Pott, C.* ; Quintanilla-Martinez, L. ; Kakadia, P. ; Kuchenbauer, F. ; Ahmed, F. ; Delabesse, E.* ; Hahn, M.* ; Lichtner, P.* ; Kneba, M. ; Hiddemann, W. ; Macintyre, E.* ; Mecucci, C.* ; Ludwig, W.D.* ; Humphries, R.K.* ; Bohlander, S.K. ; Feuring-Buske, M. ; Buske, C.

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.

Cancer Cell 10, 363-374 (2006)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. Furthermore, depletion of B220+ cells in leukemic transplants impaired development of leukemia in recipients. As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells. These data demonstrate in a murine leukemia model that AML can be propagated by a transformed progenitor with lymphoid characteristics, which can be targeted by antibodies that do not crossreact with normal HSCs. © 2006 Elsevier Inc. All rights reserved.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Humdisease
Language english
Publication Year 2006
HGF-reported in Year 2006
ISSN (print) / ISBN 1535-6108
e-ISSN 1878-3686
Journal Cancer Cell
Quellenangaben Volume: 10, Issue: 5, Pages: 363-374 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
Institute of Pathology (PATH)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
Enabling and Novel Technologies
PSP Element(s) G-521000-001
G-500300-001
DOI 10.1016/j.ccr.2006.08.023
Scopus ID 33750626083
Erfassungsdatum 2006-11-22
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