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How to make neurons-thoughts on the molecular logic of neurogenesis in the central nervous system.
Cell Tissue Res. 359, 5-16 (2015)
Neuronal differentiation relies on a set of interconnected molecular events to achieve the differentiation of pan-neuronal hallmarks, together with neuronal subtype-specific features. Here, we propose a conceptual framework for these events, based on recent findings. This framework encompasses a dimension in time during development, progressing from early master regulators to later expressed effector genes and terminal selector genes. As a horizontal intersection, we propose the action of permissive fate determinants that are critical in allowing progression through the above transcriptional phases. Typically, these are widely expressed and often interact with the chromatin remodeling machinery. We conclude by discussing this model in the context of the direct fate conversion of various somatic cells into neurons.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Central Nervous System ; Direct Conversion ; Fate Determinant ; Fate Specification ; Neurogenesis ; Transcription Factor; Neural Stem-cells; Adult Hippocampal Neurogenesis; Soxc Transcription Factors; In-vivo; Dopaminergic-neurons; Olfactory-bulb; Fate Specification; Glial-cells; Progenitor Proliferation; Functional-neurons
ISSN (print) / ISBN
0044-3794
e-ISSN
1432-0878
Journal
Cell and Tissue Research
Quellenangaben
Volume: 359,
Issue: 1,
Pages: 5-16
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)