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Qi, Q.* ; Downer, M.K.* ; Kilpeläinen, T.O.* ; Taal, H.R.* ; Barton, S.J.* ; Ntalla, I.* ; Standl, M. ; Boraska, V.* ; Huikari, V.* ; Kiefte-de Jong, J.C.* ; Körner, A.* ; Lakka, T.A.* ; Liu, G.* ; Magnusson, J.* ; Okuda, M.* ; Raitakari, O.* ; Richmond, R.* ; Scott, R.A.* ; Bailey, M.E.* ; Scheuermann, K.* ; Holloway, J.W.* ; Inskip, H.M.* ; Isasi, C.R.* ; Mossavar-Rahmani, Y.* ; Jaddoe, V.W.* ; Laitinen, J.* ; Lindi, V.* ; Melén, E.* ; Pitsiladis, Y.* ; Pitkänen, N.* ; Snieder, H.* ; Heinrich, J. ; Timpson, N.J.* ; Wang, T.* ; Yuji, H.* ; Zeggini, E.* ; Dedoussis, G.V.* ; Kaplan, R.C.* ; Wylie-Rosett, J.* ; Loos, R.J.* ; Hu, F.B.* ; Qi, L.*

Dietary intake, FTO genetic variants and adiposity: A combined analysis of over 16,000 children and adolescents.

Diabetes 64, 2467-2476 (2015)
Postprint DOI PMC
Open Access Green
The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake on BMI. We found that the BMI-increasing allele (minor allele) of FTO variant was associated with increased total energy intake (effect per allele=14.3[5.9, 22.7] kcal/day, P=6.5×10(-4)) but not with protein, carbohydrate or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele=0.08[0.03, 0.12]SDs, P for interaction=7.2×10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele=0.10[0.07, 0.13]SDs, P=8.2×10(-10)) than in those with low intake (effect per allele=0.04[0.01, 0.07]SDs, P=0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Body-mass Index; Obesity-associated Gene; Energy-intake; Fat Mass; Physical-activity; Food-intake; Childhood Obesity; Cohort Profile; Metabolic-rate; Adult Obesity
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 64, Issue: 7, Pages: 2467-2476 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)