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Oxytocin reverses osteoporosis in a sex-dependent manner.
Front. Endocrin. 6:81 (2015)
The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex hormones occurring during andropause or surgical orchidectomy. As we previously demonstrated in a mouse model for menopause in women that treatment with the neurohypophyseal peptide hormone oxytocin (OT) normalizes body weight and prevents the development of osteoporosis, herein we addressed the effects of OT in male osteoporosis. Thus, we treated orchidectomized mice, an animal model suitable for the study of male osteoporosis, for 8 weeks with OT and then analyzed trabecular and cortical bone parameters as well as fat mass using micro-computed tomography. Orchidectomized mice displayed severe bone loss, muscle atrophy accompanied by fat mass gain as expected in andropause. Interestingly, OT treatment in male mice normalized fat mass as it did in female mice. However, although OT treatment led to a normalization of bone parameters in ovariectomized mice, this did not happen in orchidectomized mice. Moreover, loss of muscle mass was not reversed in orchidectomized mice upon OT treatment. All of these observations indicate that OT acts on fat physiology in both sexes, but in a sex specific manner with regard to bone physiology.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipose Tissue ; Bone ; Female ; Male ; Mice ; Orchidectomy
Language
english
Publication Year
2015
HGF-reported in Year
2015
ISSN (print) / ISBN
1664-2392
e-ISSN
1664-2392
Journal
Frontiers in Endocrinology
Quellenangaben
Volume: 6,
Article Number: 81
Publisher
Frontiers
Publishing Place
Lausanne
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
POF-Topic(s)
90000 - German Center for Diabetes Research
30201 - Metabolic Health
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-252
G-502500-001
G-502500-001
PubMed ID
26042090
Scopus ID
84930941527
Erfassungsdatum
2015-06-06