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Neurogenesis in the developing and adult brain - similarities and key differences.
Cold Spring Harbor Perspect. Biol. 8, DOI: 10.1101/cshperspect.a018853 (2015)
Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis at earlier, developmental stages. Here, we will critically review the extent to which this is the case highlighting similarities as well as key differences. Although many transcriptional regulators are shared in neurogenesis at embryonic and adult stages, recent findings on the molecular mechanisms by which these neuronal fate determinants control fate acquisition and maintenance have revealed profound differences between development and adulthood. Importantly, adult neurogenesis occurs in a gliogenic environment hence requiring adult-specific additional and unique mechanisms of neuronal fate specification and maintenance. Thus, a better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Gage, F.H.* ; Kempermann, G.* ; Song, H.*
Keywords
Neural Stem-cells; Metabotropic Glutamate Receptors; Postnatal Subventricular Zone; Olfactory-bulb Neurogenesis; Lateral Ganglionic Eminence; Transcription Factor Pax6; Rat Dentate Gyrus; Central-nervous-system; Mammalian Spinal-cord; Homeobox Gene Gsx2
e-ISSN
1943-0264
Conference Title
Additional Perspectives on Neurogenesis
Quellenangaben
Volume: 8,
Issue: 7
Publisher
Cold Spring Harbor Laboratory Press
Publishing Place
Cold Spring Harbor
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)