PuSH - Publication Server of Helmholtz Zentrum München

Pfluger, P.T. ; Kabra, D.G. ; Aichler, M. ; Schriever, S.C. ; Pfuhlmann, K. ; Casquero García, V. ; Lehti, M.* ; Weber, J.* ; Kutschke, M. ; Rozman, J. ; Elrod, J.W.* ; Hevener, A.L.* ; Feuchtinger, A. ; Hrabě de Angelis, M. ; Walch, A.K. ; Rollmann, S.M.* ; Aronow, B.J.* ; Müller, T.D. ; Perez-Tilve, D.* ; Jastroch, M. ; de Luca, M.* ; Molkentin, J.D.* ; Tschöp, M.H.

Calcineurin links mitochondrial elongation with energy metabolism.

Cell Metab. 22, 838-850 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Canonical protein phosphatase 3/calcineurin signaling is central to numerous physiological processes. Here we provide evidence that calcineurin plays a pivotal role in controlling systemic energy and body weight homeostasis. Knockdown of calcineurin in Drosophila melanogaster led to a decrease in body weight and energy stores, and increased energy expenditure. In mice, global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity and comorbid sequelæ. Ser637 hyperphosphorylation of dynamin-related protein 1 (Drp1) in skeletal muscle of calcineurin-deficient mice was associated with mitochondrial elongation into power-cable-shaped filaments and increased mitochondrial respiration, but also with attenuated exercise performance. Our data suggest that calcineurin acts as highly conserved pivot for the adaptive metabolic responses to environmental changes such as high-fat, high-sugar diets or exercise.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 22, Issue: 5, Pages: 838-850 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)
Institute of Experimental Genetics (IEG)