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Marenholz, I.* ; Esparza-Gordillo, J.* ; Ruschendorf, F.* ; Bauerfeind, A.* ; Strachan, D.P.* ; Spycher, B.D.* ; Baurecht, H. ; Margaritte-Jeannin, P.* ; Saaf, A.* ; Kerkhof, M.* ; Ege, M.* ; Baltic, S.* ; Matheson, M.C.* ; Li, J.* ; Michel, S.* ; Ang, W.Q.* ; McArdle, W.* ; Arnold, A.* ; Homuth, G.* ; Demenais, F.* ; Bouzigon, E.* ; Söderhäll, C.* ; Pershagen, G.* ; de Jongste, J.C.* ; Postma, D.S.* ; Braun-Fahrländer, C.* ; Horak, E.* ; Ogorodova, L.M.* ; Puzyrev, V.P.* ; Bragina, E.Y.* ; Hudson, T.J.* ; Morin, C.* ; Duffy, D.L.* ; Marks, G.B.* ; Robertson, C.F.* ; Montgomery, G.W.* ; Musk, B.* ; Thompson, P.J.* ; Martin, N.G.* ; James, A.* ; Sleiman, P.M.* ; Toskala, E. ; Rodriguez, E.* ; Fölster-Holst, R.* ; Franke, A.* ; Lieb, W.* ; Gieger, C. ; Heinzmann, A.* ; Rietschel, E.* ; Keil, T.* ; Cichon, S.* ; Nöthen, M.M.* ; Pennell, C.E.* ; Sly, P.D.* ; Schmidt, C.O.* ; Matanovic, A.* ; Schneider, V.* ; Heinig, M.* ; Hubner, N.* ; Holt, P.G.* ; Lau, S.* ; Kabesch, M.* ; Weidinger, S.* ; Hakonarson, H.* ; Ferreira, M.A.* ; Laprise, C.* ; Freidin, M.B.* ; Genuneit, J.* ; Koppelman, G.H.* ; Melén, E.* ; Dizier, M.H.* ; Henderson, A.J.* ; Lee, Y.A.*

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Nat. Commun. 6:8804 (2015)
Publ. Version/Full Text Supplement DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 6, Issue: , Pages: , Article Number: 8804 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)