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Papandonatos, G.D.* ; Pan, Q.* ; Pajewski, N.M.* ; Delahanty, L.M.* ; Peter, I.* ; Erar, B.* ; Ahmad, S.* ; Harden, M.* ; Chen, L.* ; Fontanillas, P.* ; GIANT Consortium (Albrecht, E. ; Gieger, C. ; Grallert, H. ; Heid, I.M. ; Illig, T. ; Müller-Nurasyid, M. ; Peters, A. ; Thorand, B. ; Wichmann, H.-E.) ; Wagenknecht, L.E.* ; Kahn, S.E.* ; Wing, R.R.* ; Jablonski, K.A.* ; Huggins, G.S.* ; Knowler, W.C.* ; Florez, J.C* ; McCaffery, J.M.* ; Franks, P.W.* ; Diabetes Prevention Program (*) ; Look AHEAD Research Group (*)

Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.

Diabetes 64, 4312-4321 (2015)
Publ. Version/Full Text Research data DOI
Open Access Green as soon as Postprint is submitted to ZB.
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10−7). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer’s neurodegeneration.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 64, Issue: 12, Pages: 4312-4321 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)