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Veronesi, G.* ; Ferrario, M.M.* ; Kuulasmaa, K.* ; Bobak, M.* ; Chambless, L.E.* ; Salomaa, V.* ; Söderberg, S.* ; Pajak, A.* ; Jørgensen, T.* ; Amouyel, P.* ; Arveiler, D.* ; Drygas, W.* ; Ferrieres, J.* ; Giampaoli, S.* ; Kee, F.* ; Iacoviello, L.* ; Malyutina, S.A.* ; Peters, A. ; Tamosiunas, A.* ; Tunstall-Pedoe, H.* ; Cesana, G.*

Educational class inequalities in the incidence of coronary heart disease in Europe.

Heart 102, 958-965 (2016)
Postprint Supplement DOI PMC
Open Access Green
OBJECTIVE: To estimate the burden of social inequalities in coronary heart disease (CHD) and to identify their major determinants in 15 European populations. METHODS: The MORGAM (MOnica Risk, Genetics, Archiving and Monograph) study comprised 49 cohorts of middle-aged European adults free of CHD (110 928 individuals) recruited mostly in the mid-1980s and 1990s, with comparable assessment of baseline risk and follow-up procedures. We derived three educational classes accounting for birth cohorts and used regression-based inequality measures of absolute differences in CHD rates and HRs (ie, Relative Index of Inequality, RII) for the least versus the most educated individuals. RESULTS: N=6522 first CHD events occurred during a median follow-up of 12 years. Educational class inequalities accounted for 343 and 170 additional CHD events per 100 000 person-years in the least educated men and women compared with the most educated, respectively. These figures corresponded to 48% and 71% of the average event rates in each gender group. Inequalities in CHD mortality were mainly driven by incidence in the Nordic countries, Scotland and Lithuania, and by 28-day case-fatality in the remaining central/South European populations. The pooled RIIs were 1.6 (95% CI 1.4 to 1.8) in men and 2.0 (1.7 to 2.4) in women, consistently across population. Risk factors accounted for a third of inequalities in CHD incidence; smoking was the major mediator in men, and High-Density-Lipoprotein (HDL) cholesterol in women. CONCLUSIONS: Social inequalities in CHD are still widespread in Europe. Since the major determinants of inequalities followed geographical and gender-specific patterns, European-level interventions should be tailored across different European regions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Acute Myocardial-infarction; Middle-aged Men; Case-fatality; Risk-factors; Socioeconomic Inequalities; Cardiovascular Events; Health Inequalities; Life-style; Mortality; Population
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1355-6037
e-ISSN 1468-201X
Journal Heart
Quellenangaben Volume: 102, Issue: 12, Pages: 958-965 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504090-001
DOI 10.1136/heartjnl-2015-308909
WOS ID WOS:000377548100014
Scopus ID 84958092621
PubMed ID 26849899
Erfassungsdatum 2016-02-08
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