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"Scar-cinoma": Viewing the fibrotic lung mesenchymal cell in the context of cancer biology.
Eur. Respir. J. 47, 1842-1854 (2016)
Lung cancer and pulmonary fibrosis are common, yet distinct, pathological processes that represent urgent unmet medical needs. Striking clinical and mechanistic parallels exist between these distinct disease entities. The goal of this article is to examine lung fibrosis from the perspective of cancer-associated phenotypic hallmarks, to discuss areas of mechanistic overlap and distinction, and to highlight profibrotic mechanisms that contribute to carcinogenesis. Ultimately, we speculate that such comparisons might identify opportunities to leverage our current understanding of the pathobiology of each disease process in order to advance novel therapeutic approaches for both. We anticipate that such "outside the box" concepts could be translated to a more precise and individualised approach to fibrotic diseases of the lung.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Idiopathic-pulmonary-fibrosis; Fas-induced Apoptosis; Extracellular-matrix; Tumor Stroma; In-vitro; Proliferative Characteristics; Fibroblast Accumulation; Macrophage Plasticity; Exudate Macrophages; Precision Medicine
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
0903-1936
e-ISSN
1399-3003
Journal
European Respiratory Journal
Quellenangaben
Volume: 47,
Issue: 6,
Pages: 1842-1854
Publisher
European Respiratory Society
Publishing Place
Sheffield
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-501600-003
WOS ID
WOS:000385956200031
PubMed ID
27030681
Erfassungsdatum
2016-04-15