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Gut immunity and type 1 diabetes: A mélange of microbes, diet, and host interactions?
Curr. Diab. Rep. 16:60 (2016)
Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early introduction of solid food, have been associated with increased risk for developing T1D. During the first years of life, the gut microbial community is shaped by the environment, in particular by dietary factors. Moreover, the gut microbiome has been described for its role in shaping the immune system early in life and early data suggest associations between T1D risk and alterations in gut microbial communities. In this article, we discuss environmental factors influencing the colonization process of the gut microbial community. Furthermore, we review possible interactions between the microbiome and the host that might contribute to the risk of developing T1D.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Autoimmunity ; Diet ; Environmental Factors ; Gut Microbiome ; Type 1 Diabetes; Human-milk Oligosaccharides; T-cell Responses; Increased Intestinal Permeability; Butyrate-producing Bacteria; Sulfate-reducing Bacteria; Lactic-acid Bacteria; Chain Fatty-acids; Infant Gut; Commensal Bacteria; Islet Autoimmunity
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Journal
Current Diabetes Reports
Quellenangaben
Volume: 16,
Issue: 7,
Article Number: 60
Publisher
Springer
Publishing Place
Heidelberg [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)