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Tolerance to the intestinal microbiota mediated by ROR(γt)+ cells.
Trends Immunol. 37, 477-486 (2016)
Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal immune reactivity to symbiotic microbes. The transcription factor RAR-related orphan-like γt [ROR(γt); encoded by Rorc] plays a key role in the gut for lymphoid tissue organogenesis, development of innate lymphoid cells type 3 (ILC3s) and proinflammatory type 17 T helper (Th17) cells. Surprisingly, recent research has revealed a contribution of ROR(γt)-expressing cells in a variety of tolerance mechanisms in both the innate and adaptive immune system.
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11.433
2.433
15
15
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Publication type
Article: Journal article
Document type
Review
Keywords
Immunological Tolerance ; Rar-related Orphan Receptor γt ; Microbiota ; Regulatory T Cells; Innate Lymphoid-cells; Regulatory T-cells; Ror-gamma-t; Tissue-inducer Cells; Segmented Filamentous Bacteria; Cd103(+) Dendritic Cells; Pathogenic T(h)17 Cells; Th17 Cells; Commensal Bacteria; In-vivo
Language
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Journal
Trends in Immunology
Quellenangaben
Volume: 37,
Issue: 7,
Pages: 477-486
Publisher
Elsevier
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Allergy
PSP Element(s)
G-505400-003
WOS ID
WOS:000379098200006
Scopus ID
84975165474
PubMed ID
27255270
Erfassungsdatum
2016-06-06