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Fehringer, G.* ; Kraft, P.* ; Pharoah, P.D.* ; Eeles, R.A.* ; Chatterjee, N.* ; Schumacher, F.R.* ; Schildkraut, J.M.* ; Lindström, S.* ; Brennan, P.* ; Bickeböller, H.* ; Houlston, R.S.* ; Landi, M.T.* ; Caporaso, N.E.* ; Risch, A.* ; Amin Al Olama, A.* ; Berndt, S.I.* ; Giovannucci, E.* ; Grönberg, H.* ; Kote-Jarai, Z.* ; Ma, J.* ; Muir, K.* ; Stampfer, M.J.* ; Stevens, V.L.* ; Wiklund, F.* ; Willett, W.C.* ; Goode, E.L. ; Permuth, J.B.* ; Risch, H.A.* ; Reid, B.M.* ; Bézieau, S.* ; Brenner, H.* ; Chan, A.T.* ; Chang-Claude, J.* ; Hudson, T.J.* ; Kocarnik, J.M.* ; Newcomb, P.A.* ; Schoen, R.E.* ; Slattery, M.L.* ; White, E.S.* ; Adank, M.A.* ; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) (*) ; Ahsan, H.* ; Aittomäki, K.* ; Baglietto, L.* ; Blomquist, C.H.* ; Canzian, F.* ; Czene, K.* ; Dos Santos Silva, I.* ; Eliassen, A.H.* ; Figueroa, J.D.* ; Flesch-Janys, D.* ; Fletcher, O.* ; Garcia-Closas, M.* ; Gaudet, M.M.* ; Johnson, N.* ; Hall, P.* ; Hazra, A.* ; Hein, R.* ; Hofman, A.* ; Hopper, J.L.* ; Irwanto, A.* ; Johansson, M.* ; Kaaks, R.* ; Kibriya, M.G.* ; Lichtner, P. ; Liu, J.J.* ; Lund, E.* ; Makalic, E.* ; Meindl, A.* ; Müller-Myhsok, B.* ; Muranen, T.A.* ; Nevanlinna, H.* ; Peeters, P.H.* ; Peto, J.* ; Prentice, R.L.* ; Rahman, N.* ; Sánchez, M.J.* ; Schmidt, D.F.* ; Schmutzler, R.K.* ; Southey, M.C.* ; Tamimi, R.M.* ; Travis, R.C.* ; Turnbull, C.* ; Uitterlinden, A.G.* ; Wang, Z.* ; Whittemore, A.S.* ; Yang, X.R.* ; Zheng, W.* ; Rafnar, T.* ; Gudmundsson, J.* ; Stacey, S.N.* ; Stefansson, K.* ; Sulem, P.* ; Chen, Y.A.* ; Tyrer, J.P.* ; Christiani, D.C.* ; Wei, Y.* ; Shen, H.* ; Hu, Z.* ; Shu, X.O.* ; Shiraishi, K.* ; Takahashi, A.* ; Bossé, Y.* ; Obeidat, M.* ; Nickle, D.C.* ; Timens, W.* ; Freedman, M.L.* ; Li, Q.L.* ; Seminara, D.* ; Chanock, S.J.* ; Gong, J.* ; Peters, U.* ; Gruber, S.B.* ; Colorectal Transdisciplinary Study (CORECT) (*) ; Amos, C.I.* ; Sellers, T.A.* ; Easton, D.F.* ; Hunter, D.J.* ; Haiman, C.A.* ; African American Breast Cancer Consortium (AABC) (*) ; African Ancestry Prostate Cancer Consortium (AAPC) (*) ; Henderson, B.E.* ; Hung, R.J.*

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.

Cancer Res. 76, 5103-5114 (2016)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Green
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Susceptibility Loci; Identifies 2; Genetic Polymorphisms; Aggressive Prostate; African Ancestry; Common Variants; Gastric-cancer; Cell Carcinoma; Risk Loci; Metaanalysis
ISSN (print) / ISBN 0008-5472
e-ISSN 1538-7445
Journal Cancer Research
Quellenangaben Volume: 76, Issue: 17, Pages: 5103-5114 Article Number: , Supplement: ,
Publisher American Association for Cancer Research (AACR)
Publishing Place Philadelphia, Pa.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Molecular Toxicology and Pharmacology (TOXI)