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P(URI)fying novel drivers of NASH and HCC: A feedforward loop of IL17A via white adipose tissue.
Cancer Cell 30, 15-17 (2016)
Publ. Version/Full Text
DOI
PMC
How obesity and metabolic syndrome trigger non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remains elusive. In this issue, Gomes and colleagues describe that nutrient surplus induces hepatic URI expression, triggering genotoxicity and IL17A expression, thus leading to insulin resistance, NASH, and HCC. IL17A signaling blockers might become a readily translatable therapy.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Hepatocellular-carcinoma; Liver; Tumorigenesis; Epidemiology; Prevention; Cancer; Cells; Uri
ISSN (print) / ISBN
1535-6108
e-ISSN
1878-3686
Journal
Cancer Cell
Quellenangaben
Volume: 30,
Issue: 1,
Pages: 15-17
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)