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Vogt, S. ; Baumert, J.J. ; Peters, A. ; Thorand, B. ; Scragg, R.*

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: Results from the National Health and Nutrition Examination Survey 2001-2006.

Public Health Nutr. 20, 1797-1806 (2017)
Publ. Version/Full Text Supplement DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: To examine the interaction between waist circumference (WC) and serum 25-hydroxyvitamin D (25(OH)D) level in their associations with serum lipids. DESIGN: Cross-sectional study. The associations of serum 25(OH)D with total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), LDL-C:HDL-C and TAG were examined using multiple linear regression. Effect modification by WC was assessed through cross-product interaction terms between 25(OH)D and WC categories (abdominal overweight, 80-<88 cm in females/94-<102 cm in males; abdominal obesity, ≥88 cm in females/≥102 cm in males). SETTING: The US National Health and Nutrition Examination Survey waves 2001-2006. SUBJECTS: Non-pregnant fasting participants (n 4342) aged ≥20 years. RESULTS: Lower 25(OH)D levels were significantly associated with lower HDL-C levels as well as with higher LDL-C:HDL-C and TAG levels in abdominally obese participants, but not in abdominally overweight or normal-waist participants. In contrast, lower 25(OH)D levels were associated with lower levels of total cholesterol and LDL-C in abdominally overweight and normal-waist participants only, but this association was only partly significant. However, a significant difference in the association between 25(OH)D and the lipids according to WC category was found only for LDL-C:HDL-C (P for interaction=0·02). CONCLUSIONS: Our results from this large, cross-sectional sample suggest that the association between lower 25(OH)D levels and an unfavourable lipid profile is stronger in individuals with abdominal obesity than in those with abdominal overweight or a normal WC.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Interaction ; Nhanes ; Serum Lipids ; Vitamin D ; Waist Circumference
ISSN (print) / ISBN 1368-9800
e-ISSN 1475-2727
Journal Public Health Nutrition
Quellenangaben Volume: 20, Issue: 10, Pages: 1797-1806 Article Number: , Supplement: ,
Publisher Cambridge Univ. Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)