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Linking bronchopulmonary dysplasia to adult chronic lung diseases: Role of WNT signaling.

Mol. Cell. Pediatr. 3, 34:34 (2016)
Publ. Version/Full Text DOI PMC
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Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adult Chronic Lung Diseases ; Bronchopulmonary Dysplasia (bpd) ; Lung Development ; Wnt Signaling
Language german
Publication Year 2016
HGF-reported in Year 0
ISSN (print) / ISBN 2194-7791
Quellenangaben Volume: 3, Issue: , Pages: 34 Article Number: 34 Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-551800-001
G-552100-001
PubMed ID 27718180
Erfassungsdatum 2016-10-17