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Breitner-Busch, S. ; Schneider, A.E. ; Devlin, R.B.* ; Ward-Caviness, C.K. ; Diaz-Sanchez, D.* ; Neas, L.M.* ; Cascio, W.E.* ; Peters, A. ; Hauser, E.R.* ; Shah, S.H.* ; Kraus, W.E.*

Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort.

Environ. Int. 97, 76-84 (2016)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Gold
RATIONALE: Exposure to ambient particulate matter (PM) and ozone has been associated with cardiovascular disease (CVD). However, the mechanisms linking PM and ozone exposure to CVD remain poorly understood. OBJECTIVE: This study explored associations between short-term exposures to PM with a diameter <2.5μm (PM2.5) and ozone with plasma metabolite concentrations. METHODS AND RESULTS: We used cross-sectional data from a cardiac catheterization cohort at Duke University, North Carolina (NC), USA, accumulated between 2001 and 2007. Amino acids, acylcarnitines, ketones and total non-esterified fatty acid plasma concentrations were determined in fasting samples. Daily concentrations of PM2.5 and ozone were obtained from a Bayesian space-time hierarchical model, matched to each patient's residential address. Ten metabolites were selected for the analysis based on quality criteria and cluster analysis. Associations between metabolites and PM2.5 or ozone were analyzed using linear regression models adjusting for long-term trend and seasonality, calendar effects, meteorological parameters, and participant characteristics. We found delayed associations between PM2.5 or ozone and changes in metabolite levels of the glycine-ornithine-arginine metabolic axis and incomplete fatty acid oxidation associated with mitochondrial dysfunction. The strongest association was seen for an increase of 8.1μg/m(3) in PM2.5 with a lag of one day and decreased mean glycine concentrations (-2.5% [95% confidence interval: -3.8%; -1.2%]). CONCLUSIONS: Short-term exposures to ambient PM2.5 and ozone is associated with changes in plasma concentrations of metabolites in a cohort of cardiac catheterization patients. Our findings might help to understand the link between air pollution and cardiovascular disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cardiovascular Disease ; Metabolomics ; Ozone ; Particulate Matter; Coronary-artery-disease; Air-pollution; Cardiovascular-disease; Particulate Matter; Insulin-resistance; Arginine Bioavailability; Myocardial-infarction; Markers; Risk; Metabolomics
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 97, Issue: , Pages: 76-84 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-001
G-504000-005
DOI 10.1016/j.envint.2016.10.012
WOS ID WOS:000389912900009
Scopus ID 84994045460
PubMed ID 27792908
Erfassungsdatum 2016-10-31
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