OpenSSL SSL_connect: Connection reset by peer in connection to v2.sherpa.ac.uk:443 PuSH - Publication Server of Helmholtz Zentrum München: Biomonitoring of boron: Development and characterization of a simple, reliable and quality controlled biomonitoring method.

PuSH - Publication Server of Helmholtz Zentrum München

Michalke, B.

Biomonitoring of boron: Development and characterization of a simple, reliable and quality controlled biomonitoring method.

J. Trace Elem. Med. Biol. 40, 24-29 (2017)
Postprint DOI PMC
Open Access Green
Boron exposure is of interest and concern from an occupational point of view. Usual daily boron intake is related to boron blood plasma concentration <1 mg/L and to <3 mg/L in urine, but after exposure urine concentrations are quickly elevated. Reliable boron biomonitoring, typically in urine, thus is mandatory for occupational health control institutions. This paper reports on the development of a simple, fast and reliable boron determination procedure based on inductively coupled plasma – optical emission spectrometry (ICP-OES). Major aims for this method were simplicity in sample preparation, low risk for artifacts and interferences, high precision and accuracy, possibly low costs, including lower costs for element selective detection, short total analysis time and suitability for occupational health laboratories. Precision data (serial or day-to-day) from urine and doped urine were very good: <1.5 or <2%. Accuracy was calculated from analysis of a certified reference material (ERM-CD 281), as 99% or according to recoveries of doped concentrations ranging from 102 to 109% recovery. For cross-checking ICP-OES determinations, samples were analyzed also by quadrupole ICP-qMS and by sectorfield ICP-sf-MS at low and medium resolution. Both systems confirmed ICP-OES measurements when using 11B for quantification. Determinations based on 10B however showed some bias, except with ICP-sf-MS at medium resolution. The observed elevated signals are discussed with respect to the known Ne++ interference (as an impurity in Ar), which is not separated in low resolving quadrupole ICP-MS systems or ICP-sf-MS at low resolution.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Accuracy ; Boron Biomonitoring ; Icp-ms ; Icp-optical Emission Spectrometry ; Precision ; Urine; Drinking-water; Exposure; Urine
ISSN (print) / ISBN 0946-672X
e-ISSN 1878-3252
Journal Journal of Trace Elements in Medicine and Biology
Quellenangaben Volume: 40, Issue: , Pages: 24-29 Article Number: , Supplement: ,
Publisher Urban & Fischer
Publishing Place Jena
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)