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A scavenger peptide prevents methylglyoxal induced pain in mice.
Biochim. Biophys. Acta 1863, 654-662 (2017)
Publ. Version/Full Text
Research data
DOI
The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG. It was shown to reduce the formation of albumin-MG adducts in vitro and prevented MG-induced pain by reducing plasma MG levels through the formation of peptide-MG adducts in vivo. CycK(Myr)R4E therefore presents a promising option for the treatment of pain and other diabetic complications associated with high MG levels.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diabetic Complications ; Methylglyoxal ; Pain ; Peptide ; Scavenger
ISSN (print) / ISBN
0006-3002
Journal
Biochimica et Biophysica Acta
Quellenangaben
Volume: 1863,
Issue: 3,
Pages: 654-662
Publisher
Elsevier
Non-patent literature
Publications
Institute(s)
Institute of Diabetes and Cancer (IDC)