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Steiert, S.A. ; Zissler, U.M. ; Chaker, A. ; Esser-von Bieren, J. ; Dittlein, D. ; Guerth, F. ; Jakwerth, C.A. ; Piontek, G.* ; Zahner, C.* ; Drewe, J.* ; Traidl-Hoffmann, C. ; Schmidt-Weber, C.B. ; Gilles, S.

Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway.

BioFactors 43, 388-399 (2017)

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	Open Access Green

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Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB₄ in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro-inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT-signalling pathways in HNECs and has high potential as a broad anti-inflammatory drug that exceeds current indication.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords STAT signalling; cytokines; human nasal epithelial cells; microbial patterns; petasin; viral inflammation; Intermittent Allergic Rhinitis; Inflammation; Granulocyte; Expression; Epithelium; Cytokines; Responses; Agonist; Placebo; Innate

ISSN (print) / ISBN 0951-6433

e-ISSN 1872-8081

Journal BioFactors

Quellenangaben Volume: 43, Issue: 3, Pages: 388-399

Publisher Wiley

Publishing Place Hoboken

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Allergy Research (IAF)
Institute of Environmental Medicine (IEM)