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Varela, L.* ; Suyama, S.* ; Huang, Y.* ; Shanabrough, M.* ; Tschöp, M.H. ; Gao, X.B.* ; Giodano, F.J.* ; Horvath, T.L.

Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons.

Diabetes 66, 1511-1520 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Glucose is the primary driver of hypothalamic POMC neurons. Here, we show that endothelial HIF-1α controls glucose uptake in the hypothalamus, and, that it is up-regulated in conditions of under-nourishment during which POMC neuronal activity is decreased. Endothelium-specific knockdown of HIF-1α impairs the ability of POMC neurons to adapt to the changing metabolic environment in vivo resulting in overeating of mice after food deprivation. The impaired functioning of POMC neurons was reversed ex vivo or by parenchymal glucose administration. These observations indicate an active role for endothelial cells in the central control of metabolism and suggest that central vascular impairments may cause metabolic disorders.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Agrp Neurons; Leptin Resistance; Brain; Acid; Availability; Transporters; Hif-1-alpha; Homeostasis; Signals; Barrier
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 66, Issue: 6, Pages: 1511-1520 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502200-001
DOI 10.2337/db16-1106
WOS ID WOS:000401700400011
Scopus ID 85019592094
PubMed ID 28292966
Erfassungsdatum 2017-06-13
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