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Open Access Green as soon as Postprint is submitted to ZB.
Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons.
Diabetes 66, 1511-1520 (2017)
Publ. Version/Full Text
Research data
DOI
PMC
Glucose is the primary driver of hypothalamic POMC neurons. Here, we show that endothelial HIF-1α controls glucose uptake in the hypothalamus, and, that it is up-regulated in conditions of under-nourishment during which POMC neuronal activity is decreased. Endothelium-specific knockdown of HIF-1α impairs the ability of POMC neurons to adapt to the changing metabolic environment in vivo resulting in overeating of mice after food deprivation. The impaired functioning of POMC neurons was reversed ex vivo or by parenchymal glucose administration. These observations indicate an active role for endothelial cells in the central control of metabolism and suggest that central vascular impairments may cause metabolic disorders.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Agrp Neurons; Leptin Resistance; Brain; Acid; Availability; Transporters; Hif-1-alpha; Homeostasis; Signals; Barrier
ISSN (print) / ISBN
0012-1797
e-ISSN
1939-327X
Journal
Diabetes
Quellenangaben
Volume: 66,
Issue: 6,
Pages: 1511-1520
Publisher
American Diabetes Association
Publishing Place
Alexandria, VA.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)