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Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography.
Proc. SPIE 10064:100641B (2017)
Publ. Version/Full Text
DOI
Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Optoacoustic/photoacoustic tomography, multispectral imaging, spectral unmixing, non-negative constraint
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2017
Conference Date
28 January - 2 February 2017
Conference Location
San Francisco, California, United States
Journal
Proceedings of SPIE
Quellenangaben
Volume: 10064,
Article Number: 100641B
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)