PuSH - Publication Server of Helmholtz Zentrum München

Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.

J. Immunol. Res. 2017:4828936 (2017)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Interferon-α (IFN-α) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. In this study, we describe a novel mode of its antiviral action. We demonstrate that the supernatant from IFN-α-treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells. The factors contained in the supernatant competed with the virus for binding to heparan glycosaminoglycans-the nonspecific attachment step shared by HBV and HCV. Secreted factors of high molecular mass that bind to heparin columns elicited the antiviral effect. In conclusion, IFN-α is able to induce soluble factors that can bind to heparan glycosaminoglycans thus leading to the inhibition of viral binding.
Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Surface Heparan-sulfate; Humanized Mice; Initial Interaction; Envelope Protein; Dengue Virus; Infection; Replication; Binding; Cells; Identification
ISSN (print) / ISBN 2314-8861
e-ISSN 2314-7156
Quellenangaben Volume: 2017, Issue: , Pages: , Article Number: 4828936 Supplement: ,
Publisher Hindawi
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed