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Thienel, M. ; Wilhelm, I.* ; Benedict, C.* ; Born, J. ; Hallschmid, M.

Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans.

Neurobiol. Aging 54, 170-174 (2017)
Publ. Version/Full Text Postprint Research data DOI PMC
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Aging is associated with increases in hypothalamic-pituitary-adrenal (HPA) axis activity that can predispose to metabolic and cognitive impairments. We investigated in elderly and young subjects whether intranasal insulin administration to the human brain reduces early-sleep nadir concentrations of adrenocorticotropin and cortisol, that is, indicators of baseline HPA axis activity. In within-subject comparisons, intranasal insulin (160 IU) or placebo was administered to 14 elderly (mean age 70.0 years) and 30 young (23.6 years) healthy subjects before bedtime. Sleep was polysomnographically assessed and blood samples were repeatedly collected. Elderly compared with young participants displayed increased early-sleep cortisol concentrations (p < 0.04) and reductions in slow wave and REM sleep (p < 0.001). Insulin administration reduced cortisol levels between 2300 hours and 0020 hours in the elderly (p = 0.03) but not young participants (p = 0.56; p = 0.003 for interaction). Findings indicate that central nervous insulin acts as an inhibitory signal in basal HPA axis activity regulation and suggest that intranasal insulin may normalize sleep-associated stress axis activity in older age.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Aging ; Brain ; Cortisol ; Hypothalamic-pituitary-adrenal Axis ; Insulin ; Sleep; Human Brain; Hyperinsulinemia; Disease; Stress; Memory; Men; Age
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Journal Neurobiology of Aging
Quellenangaben Volume: 54, Issue: , Pages: 170-174 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)