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Pronicka, E.* ; Ropacka-Lesiak, M.* ; Trubicka, J.* ; Pajdowska, M.* ; Linke, M.* ; Ostergaard, E.* ; Saunders, C.* ; Horsch, S.* ; van Karnebeek, C.* ; Yaplito-Lee, J.* ; Distelmaier, F.* ; Õunap, K.* ; Rahman, S.* ; Castelle, M.* ; Kelleher, J.* ; Baris, S.* ; Iwanicka-Pronicka, K.* ; Steward, C.G.* ; Ciara, E.* ; Wortmann, S.B.

A scoring system predicting the clinical course of CLPB defect based on the foetal and neonatal presentation of 31 patients.

J. Inherit. Metab. Dis. 40, 853-860 (2017)
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Recently, CLPB deficiency has been shown to cause a genetic syndrome with cataracts, neutropenia, and 3-methylglutaconic aciduria. Surprisingly, the neurological presentation ranges from completely unaffected to patients with virtual absence of development. Muscular hypo- and hypertonia, movement disorder and progressive brain atrophy are frequently reported. We present the foetal, peri- and neonatal features of 31 patients, of which five are previously unreported, using a newly developed clinical severity scoring system rating the clinical, metabolic, imaging and other findings weighted by the age of onset. Our data are illustrated by foetal and neonatal videos. The patients were classified as having a mild (n = 4), moderate (n = 13) or severe (n = 14) disease phenotype. The most striking feature of the severe subtype was the neonatal absence of voluntary movements in combination with ventilator dependency and hyperexcitability. The foetal and neonatal presentation mirrored the course of disease with respect to survival (current median age 17.5 years in the mild group, median age of death 35 days in the severe group), severity and age of onset of all findings evaluated. CLPB deficiency should be considered in neonates with absence of voluntary movements, respiratory insufficiency and swallowing problems, especially if associated with 3-methylglutaconic aciduria, neutropenia and cataracts. Being an important differential diagnosis of hyperekplexia (exaggerated startle responses), we advise performing urinary organic acid analysis, blood cell counts and ophthalmological examination in these patients. The neonatal presentation of CLPB deficiency predicts the course of disease in later life, which is extremely important for counselling.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 3-methylglutaconic Aciduria ; Cataracts ; Hyperekplexia ; Neutropenia ; Prenatal Movement Disorder ; Prenatal Seizures; 3-methylglutaconic Aciduria; Protein Disaggregation; Congenital Neutropenia; Mutations; Disorder; Cataract
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0141-8955
e-ISSN 1573-2665
Journal Journal of Inherited Metabolic Disease
Quellenangaben Volume: 40, Issue: 6, Pages: 853-860 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Dordrecht
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
DOI 10.1007/s10545-017-0057-z
WOS ID WOS:000413299800011
Scopus ID 85022078032
PubMed ID 28687938
Erfassungsdatum 2017-07-24
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