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Beyerlein, A. ; Donnachie, E.* ; Ziegler, A.-G.

Infections in early Life and development of celiac disease.

Am. J. Epidemiol. 186, 1277-1280 (2017)
Publ. Version/Full Text Postprint Research data Research data DOI PMC
Open Access Green
Early infections have been suggested to be associated with increased risk for later celiac disease (CD). We analyzed prospective claims data of n = 295,420 infants from Bavaria, Germany, born between 2005 and 2007 containing information on medically attended infectious diseases according to ICD-10 code on a quarterly basis to calculate hazard ratios and 95% confidence intervals of time to CD diagnosis by infection exposure, adjusting for sex, calendar month of birth and number of previous healthcare visits. CD risk was increased in children who had a gastrointestinal infection during the first year of life (hazard ratio = 1.32, 95% confidence interval: 1.12, 1.55) and to a lesser extent also in children with a respiratory infection during the first year (hazard ratio = 1.22, 95% confidence interval: 1.04, 1.43). Repeated gastrointestinal infections during the first year of life were associated with particularly increased CD risk in later life. These findings indicate that early gastrointestinal infections may be relevant for CD development.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords celiac disease, gastrointestinal infections, respiratory infections; celiac disease gastrointestinal infections child communicable diseases germany infant respiratory tract infections infection diagnosis international classification of diseases elderly
ISSN (print) / ISBN 0002-9262
e-ISSN 1476-6256
Journal American Journal of Epidemiology
Quellenangaben Volume: 186, Issue: 11, Pages: 1277-1280 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Cary
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)