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Tiedemann, H.B. ; Schneltzer, E. ; Zeiser, S. ; Rubio-Aliaga, I. ; Wurst, W. ; Beckers, J. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.

Cell-based simulation of dynamic expression patterns in the presomitic mesoderm.

J. Theor. Biol. 248, 120-129 (2007)
Postprint DOI
Open Access Green
To model dynamic expression patterns in somitogenesis we developed a Java-application for simulating gene regulatory networks in many cells in parallel and visualising the results using the Java3D API, thus simulating the collective behaviour of many thousand cells. According to the ‘clock-and-wave-front’ model mesodermal segmentation of vertebrate embryos is regulated by a ‘segmentation clock’, which oscillates with a period of about 2 h in mice, and a ‘wave front’ moving back with the growing caudal end of the presomitic mesoderm. The clock is realised through cycling expression of genes such as Hes1 and Hes7, whose gene products repress the transcription of their encoding genes in a negative feedback loop. By coupling the decay of the Hes1 mRNA to a gradient with the same features and mechanism of formation as the mesodermal Fgf8 gradient we can simulate typical features of the dynamic expression pattern of Hes1 in the presomitic mesoderm. Furthermore, our program is able to synchronise Hes1 oscillations in thousands of cells through simulated Delta–Notch signalling interactions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Somitogenesis; Object-oriented modelling; Hes1; Fgf8 gradient; Delta–Notch signalling
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0022-5193
e-ISSN 1095-8541
Journal Journal of Theoretical Biology
Quellenangaben Volume: 248, Issue: 1, Pages: 120-129 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Biomathematics and Biometry (IBB)
Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30201 - Metabolic Health
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s) FE 73821
G-500600-003
G-500500-001
DOI 10.1016/j.jtbi.2007.05.014
Scopus ID 34547697590
Erfassungsdatum 2007-08-29
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