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Hofmann, S. ; Dehn, S.* ; Businger, R.* ; Bolduan, S. ; Schneider, M. ; Debyser, Z.* ; Brack-Werner, R. ; Schindler, M.

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.

Open Biol. 7:170115 (2017)

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Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a putative HIV-1 restriction factor. Early in the HIV-1 replication cycle PHF13 increased the number of integrated proviral copies and the number of infected cells. However, after HIV-1 integration, high levels of PHF13 suppressed viral gene expression. The antiviral activity of PHF13 is counteracted by the viral accessory protein Vpr, which mediates PHF13 degradation. Altogether, the transcriptional master regulator and chromatin binding protein PHF13 does not have purely repressive effects on HIV-1 replication, but also promotes viral integration. By the functional characterization of the dual role of PHF13 during the HIV-1 replication cycle, we reveal a surprising and intricate mechanism through which HIV-1 might regulate the switch from integration to viral gene expression. Furthermore, we identify PHF13 as a cellular target specifically degraded by HIV-1 Vpr.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hiv-1 ; Phf13 ; Vpr ; Integration ; Virus Restriction Factor; Tissue Ex-vivo; Glycogen-synthase Kinase-3; Dna-damage Response; Virus Type-1 Vpr; T-cell Depletion; Restriction Factor; Latent Infection; Viral Expression; Ubiquitin Ligase; Site Selection

e-ISSN 2046-2441

Journal Open Biology

Quellenangaben Volume: 7, Issue: 10, Article Number: 170115

Publisher Royal Society of London

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)