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Open Access Green as soon as Postprint is submitted to ZB.
NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38.
FEBS Lett. 592, 130-146 (2017)
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Research data
DOI
PMC
Ras homolog enriched in brain (Rheb) is a small GTPase that regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) and, thereby, cell growth and metabolism. Here we show that cycling between the inactive GDP-and the active GTP-bound state modulates the backbone dynamics of a C-terminal truncated form, RhebDCT, which is suggested to influence its interactions. We further investigated the interactions between RhebDCT and the proposed Rheb-binding domain of the regulatory protein FKBP38. The observed weak interactions with the GTP-analogue(GppNHp-) but not the GDP-bound state, appear to accelerate the GDP to GTP exchange, but only very weakly compared to a genuine GEF. Thus, FKBP38 is most likely not a GEF but a Rheb effector that may function in membrane targeting of Rheb.
Impact Factor
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Times Cited
Times Cited
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3.623
0.885
4
5
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Backbone Dynamics ; Fkbp38 ; Gtpase ; Nucleotide Exchange Rate ; Protein-protein Interactions ; Rheb; Guanine-nucleotide Exchange; Sequence-specific H-1; Tsc2 Gap Activity; Mammalian Target; Cell-growth; Amino-acids; Conformational States; Inhibits Apoptosis; Rapamycin Mtor; Ras Protein
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Quellenangaben
Volume: 592,
Issue: 1,
Pages: 130-146
Publisher
Elsevier
Publishing Place
Hoboken
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)
POF-Topic(s)
30203 - Molecular Targets and Therapies
30505 - New Technologies for Biomedical Discoveries
30505 - New Technologies for Biomedical Discoveries
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-503000-001
G-503000-006
G-503000-006
WOS ID
WOS:000427472500014
Scopus ID
85037978479
PubMed ID
29194576
Erfassungsdatum
2017-12-28