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Dreher, C.* ; Habermehl, D. ; Jäkel, O.* ; Combs, S.E.

Effective radiotherapeutic treatment intensification in patients with pancreatic cancer: Higher doses alone, higher RBE or both?

Radiat. Oncol. 12:203 (2017)
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Pancreatic cancer, especially in case of locally advanced stage has a poor prognosis. Radiotherapy in general can lead to tumor volume reduction, but further improvements, such as ion beam therapy have to be promoted in order to enable dose escalation, which in turn results in better local control rates and downsizing of the tumor itself. Ion beam therapy with its highly promising physical properties is also accompanied by distinct inter- and intrafractional challenges in case of robustness. First clinical results are promising, but further research in motion mitigation and biological treatment planning is necessary, in order to determine the best clinical rationales and conditions of ion beam therapy of pancreatic cancer. This review summarizes the current knowledge and studies on ion beam therapy of pancreatic cancer.
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Publication type Article: Journal article
Document type Review
Keywords Carbon Ions ; Ion Beam Therapy ; Pancreatic Cancer ; Particle Radiotherapy ; Protons ; Rbe; Stereotactic Body Radiotherapy; Carbon-ion Radiotherapy; Proton-beam Therapy; Radiation-therapy; Fractionated Chemoradiation; Duodenal Toxicity; Target Volume; Spinal-cord; Dosimetric Analysis; Motion Mitigation
Language
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Journal Radiation Oncology
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 203 Supplement: ,
Publisher BioMed Central
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
PubMed ID 29282139
DOI 10.1186/s13014-017-0945-2
WOS ID WOS:000419159400001
Scopus ID 85039912183
Erfassungsdatum 2018-01-11
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