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Dalke, C. ; Neff, F. ; Bains, S.K.* ; Bright, S.* ; Lord, D.J.* ; Reitmeir, P. ; Rößler, U.* ; Samaga, D.* ; Unger, K. ; Braselmann, H. ; Wagner, F. ; Greiter, M. ; Gomolka, M.* ; Hornhardt, S.* ; Kunze, S. ; Kempf, S.J.* ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Rosemann, M. ; Azimzadeh, O. ; Tapio, S. ; Aubele, M. ; Theis, F.J. ; Hoeschen, C. ; Slijepcevic, P.* ; Kadhim, M.* ; Atkinson, M.J. ; Zitzelsberger, H. ; Kulka, U.* ; Graw, J.

Lifetime study in mice after acute low-dose ionizing radiation: A multifactorial study with special focus on cataract risk.

Radiat. Environ. Biophys. 57, 99-113 (2018)

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Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Radiation-induced Cataract ; Mouse ; Low-dose Radiation ; Scheimpflug Analysis

ISSN (print) / ISBN 0301-634X

e-ISSN 1432-2099

Journal Radiation and Environmental Biophysics

Quellenangaben Volume: 57, Issue: 2, Pages: 99-113

Publisher Springer

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Developmental Genetics (IDG)
Institute of Metabolism and Cell Death (MCD)
Institute of Experimental Genetics (IEG)
Institute of Health Economics and Health Care Management (IGM)
Translational Metabolic Oncology (TMO)
Institute of Radiation Medicine (IRM)
Auswertungsstelle (AWST)
Institute of Radiation Biology (ISB)
Research Unit Analytical Pathology (AAP)
Institute of Computational Biology (ICB)
Institute of Radiation Protection (ISS)