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Dalke, C. ; Neff, F. ; Bains, S.K.* ; Bright, S.* ; Lord, D.J.* ; Reitmeir, P. ; Rößler, U.* ; Samaga, D.* ; Unger, K. ; Braselmann, H. ; Wagner, F. ; Greiter, M. ; Gomolka, M.* ; Hornhardt, S.* ; Kunze, S. ; Kempf, S.J.* ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Rosemann, M. ; Azimzadeh, O. ; Tapio, S. ; Aubele, M. ; Theis, F.J. ; Hoeschen, C. ; Slijepcevic, P.* ; Kadhim, M.* ; Atkinson, M.J. ; Zitzelsberger, H. ; Kulka, U.* ; Graw, J.

Lifetime study in mice after acute low-dose ionizing radiation: A multifactorial study with special focus on cataract risk.

Radiat. Environ. Biophys. 57, 99-113 (2018)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Radiation-induced Cataract ; Mouse ; Low-dose Radiation ; Scheimpflug Analysis
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 57, Issue: 2, Pages: 99-113 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Metabolism and Cell Death (MCD)
Institute of Experimental Genetics (IEG)
Institute of Health Economics and Health Care Management (IGM)
Translational Metabolic Oncology (IDC-TMO)
Institute of Radiation Medicine (IRM)
Auswertungsstelle (AWST)
Institute of Radiation Biology (ISB)
Research Unit Analytical Pathology (AAP)
Institute of Computational Biology (ICB)
Institute of Radiation Protection (ISS)
POF-Topic(s) 30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
30201 - Metabolic Health
30202 - Environmental Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
Radiation Sciences
Enabling and Novel Technologies
PSP Element(s) G-500500-002
G-506900-001
G-500600-001
G-505300-002
G-501000-001
G-501391-001
A-660200-001
G-500692-001
G-500500-001
G-500200-001
G-501300-001
G-500390-001
G-503800-001
G-501100-008
DOI 10.1007/s00411-017-0728-z
WOS ID WOS:000430188900002
Scopus ID 85040337867
PubMed ID 29327260
Erfassungsdatum 2018-01-26
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