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Kleinert, M. ; Clemmensen, C.* ; Sjøberg, K.A.* ; Carl, C.S.* ; Jeppesen, J.F.* ; Wojtaszewski, J.F.P.* ; Kiens, B.* ; Richter, E.A.*

Exercise increases circulating GDF15 in humans.

Mol. Metab. 9, 187-191 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Skeletal Muscle ; Growth Differentiation Factor 15 ; Recovery ; Physical Activity; Differentiation Factor 15; Activated Protein-kinase; Tgf-beta Superfamily; Weight-loss; Receptor; Muscle; Cytokine; Ligand; Mic-1
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 9, Issue: , Pages: 187-191 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)