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Exercise increases circulating GDF15 in humans.
Mol. Metab. 9, 187-191 (2018)
Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Skeletal Muscle ; Growth Differentiation Factor 15 ; Recovery ; Physical Activity; Differentiation Factor 15; Activated Protein-kinase; Tgf-beta Superfamily; Weight-loss; Receptor; Muscle; Cytokine; Ligand; Mic-1
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
2212-8778
e-ISSN
2212-8778
Journal
Molecular Metabolism
Quellenangaben
Volume: 9,
Pages: 187-191
Publisher
Elsevier
Publishing Place
Amsterdam
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502200-001
WOS ID
WOS:000429085000016
Scopus ID
85041703305
PubMed ID
29398617
Erfassungsdatum
2018-05-09