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as soon as is submitted to ZB.
Immune preventive approaches for type-1-diabetes.
Med. Monatsschr. Pharm. 41, 105-109 (2018)
Type-1-diabetes is one of the most common chronic diseases of childhood. Children with type-1-diabetes need life-long insulin treatment, with enormous consequences for the child and its family. Years to months before clinical symptoms of type-1-diabetes onset appear, subclinical destruction of the insulin producing beta cells takes place. This process is identified by circulating islet autoantibodies to beta cell antigens, and is mediated by a lack of immunological tolerance [20]. Several immune preventive approaches could already show that administration of the antigen insulin delays type-1-diabetes onset by involving the induction of insulin-specific regulatory T cells [5, 7] . Antigen-specific therapy with insulin before or immediately after the development of autoantibodies may induce the protective immune response that prevents the emergence of autoimmunity and type-1-diabetes.
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Publication type
Article: Journal article
Document type
Review
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
0342-9601
Quellenangaben
Volume: 41,
Issue: 3,
Pages: 105-109
Publisher
Dt. Apotheker Verl.
Publishing Place
Stuttgart
Institute(s)
Institute of Diabetes Research (IDF)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502100-001
Scopus ID
85042906849
Erfassungsdatum
2018-06-18