PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Hüls, A.* ; Klümper, C.* ; MacIntyre, E.A.* ; Brauer, M.* ; Melén, E.* ; Bauer, M.* ; Berdel, D.* ; Bergström, A.* ; Brunekreef, B.* ; Chan-Yeung, M.* ; Fuertes, E.* ; Gehring, U.* ; Gref, A.* ; Heinrich, J. ; Standl, M. ; Lehmann, I.* ; Kerkhof, M.* ; Koppelman, G.H.* ; Kozyrskyj, A.L.* ; Pershagen, G.* ; Carlsten, C.* ; Krämer, U.* ; Schikowski, T.*

Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life.

Pediatr. Allergy Immunol. 29, 596-605 (2018)
Postprint DOI PMC
Open Access Green
BackgroundAssociations between traffic-related air pollution (TRAP) and childhood atopic dermatitis (AD) remain inconsistent, possibly due to unexplored gene-environment interactions. The aim of this study was to examine whether a potential effect of TRAP on AD prevalence in children is modified by selected single nucleotide polymorphisms (SNPs) related to oxidative stress and inflammation.MethodsDoctor-diagnosed AD up to age 2years and at 7-8years, as well as AD symptoms up to age 2years, was assessed using parental-reported questionnaires in six birth cohorts (N=5685). Associations of nitrogen dioxide (NO2) estimated at the home address of each child at birth and nine SNPs within the GSTP1, TNF, TLR2, or TLR4 genes with AD were examined. Weighted genetic risk scores (GRS) were calculated from the above SNPs and used to estimate combined marginal genetic effects of oxidative stress and inflammation on AD and its interaction with TRAP.ResultsGRS was associated with childhood AD and modified the association between NO2 and doctor-diagnosed AD up to the age of 2years (P(interaction)=.029). This interaction was mainly driven by a higher susceptibility to air pollution in TNF rs1800629 minor allele (A) carriers. TRAP was not associated with the prevalence of AD in the general population.ConclusionsThe marginal genetic association of a weighted GRS from GSTP1, TNF, TLR2, and TLR4SNPs and its interaction with air pollution supports the role of oxidative stress and inflammation in AD.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.137
1.214
24
25
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Atopic Eczema ; Gene-environment Interaction ; Weighted Genetic Risk Scores; Childhood Asthma; Birth Cohort; Exposure; Health; Eczema; Susceptibility; Sensitization; Association; Population; Children
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 29, Issue: 6, Pages: 596-605 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
DOI 10.1111/pai.12903
WOS ID WOS:000442500100004
Scopus ID 85046549131
PubMed ID 29624745
Erfassungsdatum 2018-06-20
[➜Report correction]