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Localization optoacoustic tomography.
Light Sci. Appl. 7, 18004:18004 (2018)
Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein, we introduce a new concept of localization optoacoustic tomography (LOT) that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles. We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions. Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters, LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acoustic Diffraction ; Limited-view Effects ; Localization ; Optoacoustic Imaging ; Photoacoustic Imaging ; Super-resolution
ISSN (print) / ISBN
2047-7538
e-ISSN
2047-7538
Journal
Light: Science & Applications
Quellenangaben
Volume: 7,
Pages: 18004
Article Number: 18004
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)