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Kyriakou, E. ; Kostagianni, A.D.* ; Kellici, T.F.* ; Giannopoulou, E.A.* ; Siatis, K.E.* ; Sayyad, N.* ; Kalofonos, H.P.* ; Mavromoustakos, T.* ; Stamatis, H.* ; Tzakos, A.G.*

Three regioselectively acylated flavonoid aglycone derivatives in equimolar yield at one blow.

ChemistrySelect 3, 5207-5211 (2018)
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Open Access Green
A simple and time‐effective chemoenzymatic process to obtain three regioselective acylated quercetin analogues in a 1:1:1 ratio in one pot is described. This process overcomes the inherent scaffold intricacy and synthetic complexity of quercetin. Cell proliferation experiments in three breast cancers cell lines pinpoint the high potency of the generated compounds.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biocatalysis ; Cancer ; Quercetin ; In Silico Studies ; Nmr Experiments ; Regioselectivity
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2365-6549
e-ISSN 2365-6549
Journal ChemistrySelect
Quellenangaben Volume: 3, Issue: 18, Pages: 5207-5211 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Structural Biology (STB)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503000-001
DOI 10.1002/slct.201703002
WOS ID WOS:000432225900029
Scopus ID 85047546938
Erfassungsdatum 2018-06-11
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