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Brandt, S. ; Kleinert, M. ; Tschöp, M.H. ; Müller, T.D.

Are peptide conjugates the golden therapy against obesity?

J. Endocrinol. 238, R109-R119 (2018)
Publ. Version/Full Text Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Obesity is a worldwide pandemic, which can be fatal for the most extremely affected individuals. Lifestyle interventions such as diet and exercise are largely ineffective and current anti-obesity medications offer little in the way of significant or sustained weight loss. Bariatric surgery is effective, but largely restricted to only a small subset of extremely obese patients. While the hormonal factors mediating sustained weight loss and remission of diabetes by bariatric surgery remain elusive, a new class of polypharmacological drugs shows potential to shrink the gap in efficacy between a surgery and pharmacology. In essence, this new class of drugs combines the beneficial effects of several independent hormones into a single entity, thereby combining their metabolic efficacy to improve systems metabolism. Such unimolecular drugs include single molecules with agonism at the receptors for glucagon, glucagon-like peptide 1 and the glucose-dependent insulinotropic polypeptide. In preclinical studies, these specially tailored multiagonists outperform both their mono-agonist components and current best in class anti-obesity medications. While clinical trials and vigorous safety analyses are ongoing, these drugs are poised to have a transformative effect in anti-obesity therapy and might hopefully lead the way to a new era in weight-loss pharmacology.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Diabetes ; Metabolism ; Obesity ; Peptides
ISSN (print) / ISBN 0022-0795
e-ISSN 1479-6805
Journal Journal of Endocrinology
Quellenangaben Volume: 238, Issue: 2, Pages: R109-R119 Article Number: , Supplement: ,
Publisher Society for Endocrinology
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)