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Dedic, N.* ; Kuehne, C.* ; Jakovcevski, M.* ; Hartmann, J.* ; Genewsky, A.J.* ; Gomes, K.S.* ; Anderzhanova, E.* ; Poehlmann, M.L.* ; Chang, S.* ; Kolarz, A.* ; Vogl, A.M.* ; Dine, J.* ; Metzger, M.W.* ; Schmid, B.* ; Almada, R.C.* ; Ressler, K.J.* ; Wotjak, C.T.* ; Grinevich, V.* ; Chen, A.* ; Schmidt, M.V.* ; Wurst, W. ; Refojo, D.* ; Deussing, J.M.*

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Nat. Neurosci. 21, 803-807 (2018)
Postprint Research data DOI PMC
Open Access Green
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Journal Nature Neuroscience
Quellenangaben Volume: 21, Issue: 6, Pages: 803-807 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)