PuSH - Publication Server of Helmholtz Zentrum München: Genetic modifiers of radon-induced lung cancer risk: A genome-wide interaction study in former uranium miners.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Rosenberger, A.* ; Hung, R.J.* ; Christiani, D.C.* ; Caporaso, N.E.* ; Liu, G.* ; Bojesen, S.E.* ; Le Marchand, L.* ; Haiman, C.A.* ; Albanes, D.* ; Aldrich, M.C.* ; Tardón, A.* ; Fernández-Tardón, G.* ; Rennert, G.* ; Field, J.K.* ; Kiemeney, B.* ; Lazarus, P.* ; Haugen, A.* ; Zienolddiny, S.* ; Lam, S.* ; Schabath, M.B.* ; Andrew, A.S.* ; Brunnsstöm, H.* ; Goodman, G.E.* ; Doherty, J.A.* ; Chen, C.* ; Teare, M.D.* ; Wichmann, H.-E. ; Manz, J. ; Risch, A.* ; Muley, T.R.* ; Johansson, M.* ; Brennan, P.* ; Landi, M.T.* ; Amos, C.I.* ; Pesch, B.* ; Johnen, G.* ; Brüning, T.* ; Bickeböller, H.* ; Gomolka, M.*

Genetic modifiers of radon-induced lung cancer risk: A genome-wide interaction study in former uranium miners.

Int. Arch. Occup. Environ. Health 91, 937-950 (2018)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

Purpose Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon.Methods Samples from 28 studies provided by the International Lung Cancer Consortium were pooled with samples of former uranium miners collected by the German Federal Office of Radiation Protection. In total, 15,077 cases and 13,522 controls, all of European ancestries, comprising 463 uranium miners were compared. The DNA of all participants was genotyped with the OncoArray. We fitted single-marker and in multi-marker models and performed an exploratory gene-set analysis to detect cumulative enrichment of significance in sets of genes.Results We discovered a genome-wide significant interaction of the marker rs12440014 within the gene CHRNB4 (OR = 0.26, 95% CI 0.11-0.60, p = 0.0386 corrected for multiple testing). At least suggestive significant interaction of linkage disequilibrium blocks was observed at the chromosomal regions 18q21.23 (p = 1.2 x 10(-6)), 5q23.2 (p = 2.5 x 10(-6)), 1q21.3 (p = 3.2 x 10(-6)), 10p13 (p = 1.3 x 10(-5)) and 12p12.1 (p = 7.1 x 10(-5)). Genes belonging to the Gene Ontology term " DNA dealkylation involved in DNA repair" (GO: 0006307; p = 0.0139) or the gene family HGNC: 476 "microRNAs" (p = 0.0159) were enriched with LD-blockwise significance.Conclusion The well-established association of the genomic region 15q25 to lung cancer might be influenced by exposure to radon among uranium miners. Furthermore, lung cancer susceptibility is related to the functional capability of DNA damage signaling via ubiquitination processes and repair of radiation-induced double-strand breaks by the single-strand annealing mechanism.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

2.148

1.139