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Mueller, J.* ; Karrasch, S. ; Lorbeer, R.* ; Ivanovska, T.* ; Pomschar, A.* ; Kunz, W.G.* ; von Krüchten, R.* ; Peters, A. ; Bamberg, F.* ; Schulz, H. ; Schlett, C.L.*

Automated MR-based lung volume segmentation in population-based whole-body MR imaging: Correlation with clinical characteristics, pulmonary function testing and obstructive lung disease.

Eur. Radiol. 29, 1595-1606 (2019)
Postprint DOI PMC
Open Access Green
ObjectivesWhole-body MR imaging is increasingly utilised; although for lung dedicated sequences are often not included, the chest is typically imaged. Our objective was to determine the clinical utility of lung volumes derived from non-dedicated MRI sequences in the population-based KORA-FF4 cohort study.Methods400 subjects (56.4 9.2 years, 57.6% males) underwent whole-body MRI including a coronal T1-DIXON-VIBE sequence in inspiration breath-hold, originally acquired for fat quantification. Based on MRI, lung volumes were derived using an automated framework and related to common predictors, pulmonary function tests (PFT; spirometry and pulmonary gas exchange, n = 214) and obstructive lung disease.ResultsMRI-based lung volume was 4.0 1.1 L, which was 64.8 14.9% of predicted total lung capacity (TLC) and 124.4 27.9% of functional residual capacity. In multivariate analysis, it was positively associated with age, male, current smoking and height. Among PFT indices, MRI-based lung volume correlated best with TLC, alveolar volume and residual volume (RV; r = 0.57 each), while it was negatively correlated to FEV1/FVC (r = 0.36) and transfer factor for carbon monoxide (r = 0.16). Combining the strongest PFT parameters, RV and FEV1/FVC remained independently and incrementally associated with MRI-based lung volume ( = 0.50, p = 0.04 and = - 0.02, p = 0.02, respectively) explaining 32% of the variability. For the identification of subjects with obstructive lung disease, height-indexed MRI-based lung volume yielded an AUC of 0.673-0.654.Conclusion Lung volume derived from non-dedicated whole-body MRI is independently associated with RV and FEV1/FVC. Furthermore, its moderate accuracy for obstructive lung disease indicates that it may be a promising tool to assess pulmonary health in whole-body imaging when PFT is not available.Key Points Although whole-body MRI often does not include dedicated lung sequences, lung volume can be automatically derived using dedicated segmentation algorithms Lung volume derived from whole-body MRI correlates with typical predictors and risk factors of respiratory function including smoking and represents about 65% of total lung capacity and 125% of the functional residual capacity Lung volume derived from whole-body MRI is independently associated with residual volume and the ratio of forced expiratory volume in 1 s to forced vital capacity and may allow detection of obstructive lung disease
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Magnetic Resonance Imaging ; Whole-body Imaging ; Computer-assisted Image Analysis ; Pulmonary Function Test ; Obstructive Lung Disease; Copd; Burden; Standardization; Spirometry; Management; Emphysema; Diagnosis; Asthma; Kora; Ct
ISSN (print) / ISBN 0938-7994
e-ISSN 1432-1084
Journal European Radiology
Quellenangaben Volume: 29, Issue: 3, Pages: 1595-1606 Article Number: , Supplement: ,
Publisher Springer
Publishing Place 233 Spring St, New York, Ny 10013 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)