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Popp, D.* ; Aertsen, S. ; Luetke-Daldrup, C.* ; Coppenrath, E.* ; Hetterich, H.* ; Saam, T.* ; Rottenkolber, M. ; Seissler, J. ; Lechner, A. ; Sommer, N.N.*

No correlation of pancreatic fat and β-cell function in young women with and without a history of gestational diabetes.

J. Clin. Endocrinol. Metab. 103, 3260-3266 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Context: Pancreatic steatosis may contribute to b-cell dysfunction in type 2 diabetes (T2D), but data are controversial. Women who had gestational diabetes mellitus (GDM) are at high risk for developing T2D. Objective: To examine the association of pancreatic fat content with early/first-phase insulin secretion (as markers of b-cell function). Design: Cross-sectional analysis of a subcohort of the monocentric, prospective cohort study titled Prediction, Prevention, and Subclassification of Type 2 Diabetes. Setting: Ludwig Maximilians University Hospital, Munich, Germany. Participants: Ninety-seven women, 3 to 16 months after pregnancy [41 normoglycemic women post-GDM, 19 women post-GDM with pathological glucose metabolism, and 37 normoglycemic women after a normoglycemic pregnancy (controls)]. Main Outcome Measures: Correlation of MRI-measured pancreatic fat content with early insulin release in an oral glucose tolerance test (OGGT) [insulin increment within the first 30 minutes of the OGTT (IR30)] and first-phase insulin response (FPIR) in an intravenous glucose tolerance test (n = 65), both adjusted for insulin sensitivity index (ISI). Results: Pancreatic fat content did not correlate with IR30 and FPIR adjusted for ISI. It correlated positively with body mass index, waist circumference, liver fat, and intraabdominal fat volume. Conclusion: Pancreatic fat content does not correlate with b-cell function in a cohort of young women with different degrees of T2D risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Magnetic-resonance; Insulin-resistance; Glucose-tolerance; Steatosis; Mellitus; Humans; Secretion; Obesity; Rats; Lipotoxicity
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Journal Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben Volume: 103, Issue: 9, Pages: 3260-3266 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)