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Pancreas pathology during the natural history of type 1 diabetes.
Curr. Diab. Rep. 18:124 (2018)
Purpose of review We provide an overview of pancreas pathology in type 1 diabetes (T1D) in the context of its clinical stages.Recent findings Recent studies of pancreata from organ donors with T1D and non-diabetic donors expressing T1D-associated autoantibodies reveal pathological changes/disease mechanisms beyond the well-known loss of beta cells and lymphocytic infiltrates of the islets (insulitis), including beta-cell stress, dysfunction, and viral infections. Pancreas pathology evolves through disease stages, is asynchronous, and demonstrates a chronic disease that remains active years after diagnosis. Critically, beta-cell loss is not complete at onset, although young age is associated with increased severity.SummaryThe recognition of multiple pathogenic alterations and the chronic nature of disease mechanisms during and after the development of T1D inform improved clinical trial design and reveal additional targets for therapeutic manipulation, in the context of an expanded time window for intervention.
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Publication type
Article: Journal article
Document type
Review
Keywords
Type 1 Diabetes ; Insulitis ; Beta Cell ; Pancreas ; Islet Autoimmunity; Endoplasmic-reticulum Stress; Capsid Protein Vp1; Beta-cell Function; Islet Inflammation; Er Stress; C-peptide; T-cells; Insulin Microsecretors; Hyaluronan Synthesis; Biopsy Specimens
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Journal
Current Diabetes Reports
Quellenangaben
Volume: 18,
Issue: 11,
Article Number: 124
Publisher
Springer
Publishing Place
Heidelberg [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research Type 1 (IDF)