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Nicklaus, S.* ; Divaret-Chauveau, A.* ; Chardon, M.L.* ; Roduit, C.* ; Kaulek, V.* ; Ksiazek, E.* ; Dalphin, M.L.* ; Karvonen, A.M.* ; Kirjavainen, P.V.* ; Pekkanen, J.* ; Lauener, R.* ; Schmausser-Hechfellner, E.* ; Renz, H.* ; Braun-Fahrländer, C.* ; Riedler, J.* ; Vuitton, D.A.* ; von Mutius, E. ; Dalphin, J.-C.*

The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years.

Allergy 74, 788-798 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Background The effect of exposure to microorganisms on allergic diseases has been well studied. The protective effect of early food diversity against allergic diseases was previously shown in the PASTURE cohort study. The consumption of cheese, a food potentially rich in microbial diversity, deserves further examination. We aimed to evaluate whether cheese consumption is associated with allergic diseases. Methods In the PASTURE study (birth cohort in 5 European countries), data on feeding practices, environmental factors, and allergic diseases were collected by questionnaires from birth to 6 years (N = 931). Cheese consumption at 18 months of age was quantified in terms of frequency and diversity (ie, number of consumed types among 6 types: hard pressed, semipressed, soft, blue, fresh cheese, and cheese from the farm). Multiple logistic regressions were performed to evaluate the effect of cheese consumption on atopic dermatitis (AD), food allergy (FA), allergic rhinitis, asthma, and atopic sensitization at 6 years after adjustment for confounders of atopy. Results Cheese consumption (vs. nonconsumption) had a significant protective effect on AD (OR = 0.51 [0.29-0.90], P = 0.02) and FA (OR = 0.32, [0.15-0.71], P = 0.004), but no effect on atopic sensitization, allergic rhinitis, and asthma at 6 years. This effect on AD and FA may be related to the diversity of consumed cheeses (OR = 0.64 [0.48-0.85] per cheese type, P = 0.002; OR = 0.55 [0.33-0.92], P = 0.02, respectively). Conclusion Although reverse causality cannot totally be ruled out, cheese diversity at 18 months had a protective effect against AD and FA at 6 years in addition to the protective effect of diversity of other foods.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Allergic Disease ; Atopic Dermatitis ; Cheese ; Complementary Feeding ; Food Allergy; Farm Milk Consumption; Gut Microbiota; Antiinflammatory Properties; Intestinal Microbiota; Atopic-dermatitis; Childhood Asthma; Fatty-acids; Early-life; Hay-fever; Risk
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 74, Issue: 4, Pages: 788-798 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)