PuSH - Publication Server of Helmholtz Zentrum München

Yang, B.-Y.* ; Markevych, I. ; Heinrich, J.* ; Bowatte, G.* ; Bloom, M.S.* ; Guo, Y.* ; Dharmage, S.C.* ; Jalaludin, B.* ; Knibbs, L.D.* ; Morawska, L.* ; Qian, Z.* ; Chen, D.H.* ; Ma, H.* ; Chen, D.* ; Lin, S.* ; Yang, M.* ; Liu, K.K.* ; Zeng, X.W.* ; Hu, L.W.* ; Dong, G.H.*

Associations of greenness with diabetes mellitus and glucose-homeostasis markers: The 33 Communities Chinese Health Study.

Int. J. Hyg. Environ. Health 222, 283-290 (2019)
Postprint DOI PMC
Open Access Green
Background: Residing in greener places may be protective against diabetes mellitus (DM) but evidence is scarce and comes mainly from developed countries.Objectives: To investigate associations of residential greenness with DM prevalence and glucose-homeostasis markers in Chinese adults and whether these associations were mediated by air pollution, physical activity, and body mass index.Methods: In 2009, a total of 15,477 adults from the cross-sectional 33 Communities Chinese Health Study provided blood samples and completed a questionnaire. We considered fasting and 2-h glucose and insulin concentrations, as well as the homoeostasis model assessment of insulin resistance and beta-cell function, as glucose-homeostasis markers. DM was defined according to the American Diabetes Association's recommendations. Residential greenness was estimated by two satellite-derived vegetation indexes - Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI). Nitrogen dioxide and particulate matter <= 2.5 mu m were used as air pollution proxies. Associations were assessed by two-level adjusted logistic and linear regression models.Results: A 0.1-unit increase in NDVI500 m and SAVI(500 m) was significantly associated with lower odds of DM by factors of 0.88 (95% Confidence Interval 0.82-0.94) and 0.80 (0.72-0.90), respectively. Higher greenness was also significantly associated with lower fasting and 2-h glucose levels, 2-h insulin level, as well as lower insulin resistance and higher beta-cell function. Air pollution and body mass index significantly mediated 6.9-51.1% and 8.6-78.7% these associations, respectively, while no mediation role was observed for physical activity.Conclusions: Higher residential greenness appears to be associated with a lower prevalence of DM. This association might be due to glucose and insulin metabolism and pancreatic beta-cell function. Lower levels of air pollution and body mass index can be pathways linking greenspace to diabetes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.379
1.506
27
39
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Greenness ; Diabetes Mellitus ; Glucose ; Insulin Resistance ; Cross-sectional ; Mediation; Term Air-pollution; Insulin-resistance; Neighborhood; Hypertension; Greenspace; Adiposity; Children; Obesity; Spaces; Model
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1438-4639
e-ISSN 1618-131X
Quellenangaben Volume: 222, Issue: 2, Pages: 283-290 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam ; Boston, Mass. ; London ; New York, NY ; Oxford ; Paris ; Philadelphia, Pa. ; San Diego, Calif. ; St. Louis, Mo. ; München
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
Scopus ID 85057981937
PubMed ID 30545606
Erfassungsdatum 2018-12-21