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Transcriptional elongation and mRNA export are coregulated processes.
Genet. Res. Int. 2011:652461 (2011)
Chromatin structure complexity requires the interaction and coordinated work of a multiplicity of factors at different transcriptional regulation stages. Transcription control comprises a set of processes that ensures proper balance in the gene expression under different conditions, such as signals, metabolic states, or development. We could frame those steps from epigenetic marks to mRNA stability to support the holistic view of a fine-tune balance of final mRNA levels through mRNA transcription, export, stability, translation, and degradation. Transport of mRNA from the nucleus to the cytoplasm is a key process in regulated gene expression. Transcriptional elongation and mRNA export are coregulated steps that determine the mature mRNA levels in the cytoplasm. In this paper, recent insights into the coordination of these processes in eukaryotes will be summarised.
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Publication type
Article: Journal article
Document type
Review
Language
english
Publication Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
2090-3162
e-ISSN
2090-3154
Journal
Genetics research international
Quellenangaben
Volume: 2011,
Article Number: 652461
Publisher
Hindawi
Publishing Place
New York, NY
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)
PubMed ID
22567364
Erfassungsdatum
2019-01-17