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Molina-Navarro, M.M.* ; Martinez Jimenez, C.P. ; Rodriguez-Navarro, S.*

Transcriptional elongation and mRNA export are coregulated processes.

Genet. Res. Int. 2011:652461 (2011)
DOI PMC
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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Chromatin structure complexity requires the interaction and coordinated work of a multiplicity of factors at different transcriptional regulation stages. Transcription control comprises a set of processes that ensures proper balance in the gene expression under different conditions, such as signals, metabolic states, or development. We could frame those steps from epigenetic marks to mRNA stability to support the holistic view of a fine-tune balance of final mRNA levels through mRNA transcription, export, stability, translation, and degradation. Transport of mRNA from the nucleus to the cytoplasm is a key process in regulated gene expression. Transcriptional elongation and mRNA export are coregulated steps that determine the mature mRNA levels in the cytoplasm. In this paper, recent insights into the coordination of these processes in eukaryotes will be summarised.
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Publication type Article: Journal article
Document type Review
Corresponding Author
ISSN (print) / ISBN 2090-3162
e-ISSN 2090-3154
Quellenangaben Volume: 2011, Issue: , Pages: , Article Number: 652461 Supplement: ,
Publisher Hindawi
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)