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Yang, H. ; Olefir, I. ; Tzoumas, S.* ; Ntziachristos, V.

Synthetic data framework to estimate the minimum detectable concentration of contrast agents for multispectral optoacoustic imaging of small animals.

J. Biophotonics 12:e201900021 (2019)

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The concentrations of contrast agents for optoacoustic imaging of small animals must usually be optimized through extensive pilot experiments on a case-by-case basis. The present work describes a streamlined approach for determining the minimum detectable concentration (MDC) of a contrast agent given experimental conditions and imaging system parameters. The developed Synthetic Data Framework (SDF) allows estimation of MDCs of various contrast agents under different tissue conditions without extensive animal experiments. The SDF combines simulated optoacoustic signals from exogenously administered contrast agents with in vivo experimental signals from background tissue to generate realistic synthetic multispectral optoacoustic images. In this paper, the SDF is validated with in vivo measurements and demonstrates close agreement between SDF synthetic data and experimental data in terms of both image intensity and MDCs. Use of the SDF to estimate MDCs for fluorescent dyes and nanoparticles at different tissue depths and for imaging lesions of different sizes is illustrated.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Detection Limit ; Mdc ; Molecular Sensitivity ; Optoacoustic ; Photoacoustic Imaging ; Spectral Unmixing; Sensitivity; Tomography; Tissue

ISSN (print) / ISBN 1864-063X

e-ISSN 1864-0648

Journal Journal of Biophotonics

Quellenangaben Volume: 12, Issue: 8, Article Number: e201900021

Publisher Wiley

Publishing Place Postfach 101161, 69451 Weinheim, Germany

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)