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Nienen, M.* ; Stervbo, U.* ; Moelder, F.* ; Kaliszczyk, S.* ; Kuchenbecker, L.* ; Gayova, L.* ; Schweiger, B.* ; Juerchott, K.* ; Hecht, J.* ; Neumann, A.U. ; Rahmann, S.* ; Westhoff, T.H.* ; Reinke, P.* ; Thiel, A.* ; Babel, N.*

The role of pre-existing cross-reactive central memory CD4 T-cells in vaccination with previously unseen influenza strains.

Front. Immunol. 10:593 (2019)
Publ. Version/Full Text Research data DOI PMC
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Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains-a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Central Memory T-cell ; Clonotype Diversity ; Influenza Vaccination ; Pre-existing Cross-reactive T-cells ; Vaccination Efficacy; Original Antigenic Sin; Antibody-responses; Monoclonal-antibodies; Heterologous Immunity; Virus; Repertoire; Protection; Infection; Correlate; Vaccines
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 10, Issue: , Pages: , Article Number: 593 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-503400-001
DOI 10.3389/fimmu.2019.00593
WOS ID WOS:000463320600001
PubMed ID 31019503
Erfassungsdatum 2019-04-25
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